08/04/2021

18-month Post-Doctoral Position in Microfluidics and Macromolecular Crystallography


  • ORGANISATION/COMPANY
    Université Grenoble Alpes/Institut de Biologie Structurale
  • RESEARCH FIELD
    Chemistry
  • RESEARCHER PROFILE
    Recognised Researcher (R2)
    Established Researcher (R3)
  • APPLICATION DEADLINE
    31/05/2021 00:00 - Europe/Brussels
  • LOCATION
    France › Grenoble
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35

OFFER DESCRIPTION

We are seeking a highly motivated researcher for an 18-month post-doctoral position to develop microfluidic devices for microcrystallisation and serial X-ray crystallography experiments.

The position is part of the MicroCrys project, which will optimise the existing microchip manufacturing process, finalise the chip thermoregulation system and automate the crystallisation process via microdialysis. The post-doctoral student will also validate the equipment on test cases, with the objective to transfer the technology to the market. MicroCrys is funded by Linksium, a Société d'Accélération du Transfert de Technologies (SATT) in Grenoble Alpes which is a major player in the economic development of innovation. The selected candidate will carry out his/her research activity in the team dedicated to the MicroCrys project within the Synchrotron group (https://www.ibs.fr/research/research-groups/synchrotron-group/) at the Institut de la Biologie Structurale in Grenoble, France. The starting date should be before September 2021, preferably in June 2021.

Your task/mission:

  • Microfabrication and optimisation of the microchip manufacturing process.
  • Optimization of crystallization protocols for various protein targets used in microdialysis crystallization experiments in microfluidic chips.
  • Development of new crystallization screens.
  • In situ X-ray diffraction experiments at SOLEIL and ESRF synchrotrons using on-chip generated crystals.

Your experience/skills:

  • Design of patterns and masks.
  • Manufacture of the microfluidic mould: photolithography, soft lithography.
  • Integration of complex functions is desired (thin film deposition, plasma etching, monolayer self-assembly).
  • Experience in macromolecular crystallisation and/or X-ray crystallography will be an advantage.

Your profile:

  • PhD in Physical Chemistry (soft matter), Chemical Engeneering, Macromolecular Crystallography.
  • Open-minded, with a strong interest in (structural) biology and multi-disciplinary problems.

How to apply:

The offer will remain open until the vacancy is filled.

Relative references:

N. Junius, S. Jaho, Y. Sallaz-Damaz, F. Borel, J-B. Salmon and M. Budayova-Spano (2020) Lab Chip 20, 296-310.

N. Junius, E. Vahdatahar, E. Oksanen, J. L. Ferrer and M. Budayova-Spano (2020) J. Appl. Cryst. 53, 686-698.

More Information

Additional comments

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: PhD or equivalent
    Physics: PhD or equivalent
    Biological sciences: PhD or equivalent

Skills/Qualifications

  • Design of patterns and masks.
  • Manufacture of the microfluidic mould: photolithography, soft lithography.
  • Integration of complex functions is desired (thin film deposition, plasma etching, monolayer self-assembly).
  • Experience in macromolecular crystallisation and/or X-ray crystallography will be an advantage.

Specific Requirements

  • Open-minded, with a strong interest in (structural) biology and multi-disciplinary problems.

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
Institut de Biologie Structurale
France
Grenoble
38044
71 Avenue des Martyrs

EURAXESS offer ID: 625475

Disclaimer:

The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.

 

Please contact support@euraxess.org if you wish to download all jobs in XML.