30/03/2017

ERA Mobility and Career Day


 

The vision we have for this event is to better inform the generation of young researchers in the country about their career prospects in Europe. The focus will be on the jobs provided by the EURAXESS jobs portal, but other groups are targeted as well. Also, bring the researchers closer to the industry and develop the R&D modules in a number of companies here.

 

The ERA Mobility and Career Day will be held on the weekend of 22nd and 23rd of September in Skopje. The location will be shared between the Macedonian Academy of Sciences and Arts, and The Faculty of Computer Science and Engineering in Skopje.

The event will take place at the Faculty of Computer Science and Engineering in Skopje.

10:00 - 11:00

Science Track

Mihaela Angelova (Paris, France) Immuno-genomic profile of metastatic progression in colorectal cancer

Angel Stanoev (Dortmund, Germany) Spatial-temporal organization of EGFR-PTP interaction motifs

Daniel Trpevski (Stockholm, Sweden)- The brain as a computational device and learning by error back-propagation

11:00 - 11:30

Breakfast and Coffee

11:30 - 17:00

Career Fair

11:30 - 17:00

Poster Session

11:30 - 13:00

Plenary Session 3

Elisabeth Andre (Munich, Germany)Empowering Multimodal Behavior Analysis by Interactive Machine Learning

Irena Vodenska (Boston, Massachusetts, USA) Innovative Modeling of Cascading Failures in Global Financial Networks

13:00 - 14:00

Lunch

14:00 - 15:30

Plenary Session 4

Gabor Vattay (Budapest, Hungary) Video Pandemics: World Wide Viral Spreading of Psy's Gangnam Style

Lubomir Chitkushev (Boston, Massachusetts, USA) Internet of Things (IoT): Protocol Commonality based on RINA Principles

15:30 - 15:50

Coffee Break

15:50 - 16:30

Science Track

Zorana Sokolovska (Fribourg, Switzerland) The dynamics of plurilingualism and Europe

 

Nikola Simidzievski (Ljubljana, Slovenia) Process-based modeling of system dynamics

16:30 - 17:00

Round Table Discussions with Coffee

17:00

Closing

 

 

 

 

 

 

 

Institution

Max Planck Institute of Molecular Physiology, Dortmund

Position

Doctoral researcher

City, Country

Dortmund, Germany

Title of the talk

Spatial-temporal organization of EGFR-PTP interaction motifs

Abstract

The specificity of signal processing in living cells is determined by the spatial-temporal organization of protein interactions. To elucidate how receptor tyrosine kinases (RTKs) transduce extracellular signal information, we study the phosphorylation dynamics of the epidermal growth factor receptor (EGFR). Its response is governed by an intricate balance between its autocatalytic activation and the counteracting dephosphorylation by the protein tyrosine phosphatases (PTPs), which are distributed in diverse cellular locations. By combining imaging and modeling approaches we identify how specific EGFR activity modes emerge from the distinct, spatially regulated interaction motifs with PTPs. If shaped into a double-negative feedback motif, the EGFR-PTP interaction can provide the means for robust switch-like EGFR activation and lateral signal propagation on the membrane. Vesicular trafficking of the receptor towards the cytosol subsequently reshapes this network motif into a negative feedback, suppressing the receptor’s phosphorylation and recycling it back to the membrane. EGFR vesicular dynamics thereby couples these diverse spatial interactions with the PTPs, resulting in a coordinated phosphorylation response.  

Intro to the Speaker

Angel Stanoev holds BSc and MSc degrees in Computer Science and Electrical Engineering from the Ss Cyril and Methodius University in Skopje. Since 2014 he is a graduate student in the Koseska Lab at the Max Planck Institute of Molecular Physiology in Dortmund, working in the field of Systems Biology. His research activities consist of combining microscopy imaging with nonlinear dynamics and computational modeling approaches in studying signalling systems in cells.

 

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